Effect of transcatheter endovascular holmium-166 irradiation on neointimal formation after balloon injury in porcine coronary artery
نویسندگان
چکیده
منابع مشابه
Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury.
BACKGROUND Smooth muscle cell proliferation and extracellular matrix accumulation are the principal mechanisms leading to vascular restenosis. We have previously demonstrated the growth-inhibitory effect of antisense oligomers targeting the c-myc proto-oncogene in human smooth muscle cells. The goal of this study was to investigate whether c-myc antisense oligomers reduce neointimal formation i...
متن کاملL Effect of ACE Inhibitor , Quinapril , on Neointimal Formation after Balloon Injury
Angiotensin II (Ang II) promotes growth of vascular smooth muscle cells in vitro. Consistent with this, Ang II enhances neointimal proliferation in vivo after vascular injury, while angiotensin converting enzyme (ACE) inhibitors attenuate this process. Since tissue ACE plays a key role in the control of local Ang II production, we examined whether vascular injury resulted in an increase in vasc...
متن کاملEndothelial Dysfunction After Balloon Injury of Porcine Coronary Arteries
Background Endothelium-dependent, pertussis toxin-sensitive relaxation to 5-hydroxytryptamine (5-HT) is impaired selectively after balloon injury of porcine coronary artery, followed by regeneration of the endothelial cells. The present study was designed to test the hypothesis that 5-HT, released from aggregating platelets, affects the progression of the endothelial dysfunction. Methods and Re...
متن کاملEffect of adventitial VEGF(165) gene transfer on vascular thickening after coronary artery balloon injury.
OBJECTIVE Experimental studies have provided evidence that neovascularization is an important feature of plaque growth, and angiogenic gene therapy may, therefore, increase plaque growth. This study examined the effect of local (peri)adventitial vascular endothelial growth factor165 (VEGF) gene transfer on vascular thickening after coronary balloon injury. METHODS Two coronary arteries of 15 ...
متن کاملEffect of a Dipeptidyl Peptidase-IV Inhibitor, Des-Fluoro-Sitagliptin, on Neointimal Formation after Balloon Injury in Rats
BACKGROUND Recently, it has been suggested that enhancement of incretin effect improves cardiac function. We investigated the effect of a DPP-IV inhibitor, des-fluoro-sitagliptin, in reducing occurrence of restenosis in carotid artery in response to balloon injury and the related mechanisms. METHODS AND FINDINGS Otsuka Long-Evans Tokushima Fatty rats were grouped into four: control (normal sa...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1998
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(98)81847-0